Disaccharidase Deficiency in Pediatric Patients with Inflammatory Bowel Disease

Background: Disaccharidase (DS) deficiencies have been reported in pediatric patients with inflammatory bowel disease (IBD), but the relationship between duodenal inflammation and DS deficiency has not evaluated outside of lactase deficiency. Methods: This study assessed levels IBD who underwent endoscopy assessment activity. Records were reviewed for subtype, pathology findings, results analysis. Results: A total 136 identified. Overall, 89 (65.4%) had a diagnosis Crohn’s (CD), 31 (22.8%) ulcerative colitis (UC), 16 (11.8%) indeterminant colitis. Lactase was identified 55.9% patients, followed by maltase (19.9%), sucrase palatinase (14%), pan-deficiency (12.5%). When analyzing only CD, duodenitis more likely to exhibit deficiency, trend towards Conclusions: The most common deficiency; however, this related inflammation. Pediatric CD deficiencies, namely, sucrase, palatinase, pan-deficiency. Dietary adjustments may be warranted temporarily until is healed duodenitis.